Robotics and physical AI startups in Chicago and the Midwest, by layer: Compute → Data → Model → Interface → Application. A list for now; the artwork comes later.
A mistake or a missing company? Message me on X.
Data7
Dirac Labs
Madison, WI
Quantum (diamond magnetometer) navigation sensors for GPS-denied environments.
Source start-midwest.com
GRYFN
Indiana
Multi-sensor UAV systems capturing RGB, LiDAR and hyperspectral data (Purdue startup).
Source stories.prf.org
OneTrack
Chicago, IL
AI cameras and edge sensors on forklifts and in warehouses for safety and operations analytics (formerly Intelligent Flying Machines).
Source einpresswire.com
Reconstruct
Champaign, IL
Computer-vision reality capture that aligns site imagery to design models to track construction progress.
Source builtinchicago.org
Sensory Robotics
Cincinnati, OH
3D-camera safety systems that create safety zones around industrial robots; adapting it for Air Force hangars.
Source uc.edu
Thread
North Dakota
Autonomous drone and robotics data collection for infrastructure inspection (formerly Airtonomy).
Source blogs.und.edu
Voxel51
Ann Arbor, MI
FiftyOne data platform for curating visual and physical-AI training datasets.
Sources annarborusa.org, start-midwest.com
Model2
FreightMiner
Ann Arbor, MI
Aftermarket teleoperated-plus-autonomous driving conversion kit for commercial trucks.
Source purpose.jobs
May Mobility
Ann Arbor, MI
Autonomous vehicle driving stack and shuttle/ride-hail deployments (MPDM decision-making).
Sources roboticsroundup.substack.com, purpose.jobs
Interface6
Auxetic Robotics
Soft, motor-driven artificial-muscle structures to make humanoid robots safer and cheaper (Northwestern research team).
Source polsky.uchicago.edu
Botlink
North Dakota
Cloud-based drone operations and flight-control platform.
Source unmanned-aerial.com
Circular Wave Drive
Columbus, OH
Efficient, ruggedized speed-reducing gear systems for robotics and aerospace actuation.
Source builtin.com
Dark Matter Robotics
Champaign, IL
Robotic systems combining hardware, perception and software for industrial and research automation.
Source researchpark.illinois.edu
Tactun
Edina, MN
AI-ready hardware controllers and a no-code software platform for smart-machinery makers.
Source inven.ai
Trossen Robotics
Downers Grove, IL
Affordable robot arms, research UGVs and data-collection kits used to train physical-AI models (labs incl. DeepMind, Stanford).
Sources inven.ai, trossenrobotics.com
Application33
1872
Cincinnati, OH
AI-native, robot-driven steel fabrication factory run by its own Factory OS software.
Source pulse2.com
ABAGY Robotic Systems
Buffalo Grove, IL
Software and hardware that let manufacturers automate high-mix robotic welding with minimal programming.
Source inven.ai
Agilis Air
Youngstown, OH
Low-cost, NDAA-compliant American-made drones with GPS-denied autonomy for defense.
Source prnewswire.com
Atomic Industries
Detroit, MI
AI-driven, scalable manufacturing technology (automated tool and die / injection-mold tooling).
Source roboticsroundup.substack.com
Avea Robotics
Autonomous, collaborative floor-cleaning robots for mid-sized commercial buildings (UChicago venture challenge finalist).
Source polsky.uchicago.edu
Bedestrian
Ann Arbor, MI
Autonomous indoor/outdoor delivery robots for hospitals and facilities.
Source purpose.jobs
Blueflite
Brighton, MI
Autonomous cargo drones and drone logistics, including BVLOS organ-transport pilots.
Sources start-midwest.com, purpose.jobs
BotCrew
Duluth, MN
Autonomous construction robots and vehicle-autonomy retrofits for solar and wind projects, offered as a service.
Source inven.ai
Common Vector Robotics
Detroit, MI
Rugged autonomous ground robots for defense, logistics and field operations, with in-house components.
Source michiganbusiness.org
EarthSense
Champaign, IL
Small autonomous field robots (TerraSentia) for crop data collection and farming-as-a-service.
Source researchpark.illinois.edu
Formic
Chicago, IL
Robots-as-a-service: leases and runs packing and palletizing robots for small and mid-sized factories.
Grain Weevil
Omaha, NE
Robot that levels and sweeps grain inside bins so farmers do not have to enter them.
Sources siliconprairienews.com, agfundernews.com
Greenfield Robotics
Kansas
Swarms of small autonomous robots that mechanically cut weeds in row crops, rented per acre.
Source kansaspublicradio.org
Hire Henry
St. Louis, MO
Autonomous industrial mowers using GPS and computer vision for large commercial properties.
Source fullscale.io
Kadeya
Chicago, IL
Autonomous robotic bottling stations that sanitize, refill and dispense reusable bottles on site.
Source worldbusinesschicago.com
Motmot
Detroit, MI
Autonomous underwater robots that inspect live municipal water mains without excavation.
Sources michiganbusiness.org, purpose.jobs
Nala Robotics
Arlington Heights, IL
Robotic chef systems that cook multi-cuisine recipes automatically for restaurants and cloud kitchens.
Source builtinchicago.org
Path Robotics
Columbus, OH
AI-driven autonomous robotic welding systems for manufacturers.
Sources purpose.jobs, inven.ai, prnewswire.com
Poultry Patrol
Coralville, IA
Small camera-equipped wheeled robots that patrol turkey barns to keep birds moving and healthy.
Source kcrg.com
ReconRobotics
Edina, MN
Throwable tactical micro-robots (Throwbot) for police and military reconnaissance.
Source cbsnews.com
Refraction AI
Ann Arbor, MI
Last-mile autonomous delivery robots that ride in bike lanes in all weather.
Source purpose.jobs
RoadPrintz
Cleveland Heights, OH
Robotic road-marking (stencil painting) system mounted on trucks.
Source builtin.com
RoboTire
Detroit, MI
Automated robotic tire-changing systems for auto service shops (production in Plymouth, MI per its profile; verify current status).
Source purpose.jobs
Rowbot Systems
Minneapolis, MN
Autonomous in-row robots for cornfield tasks such as nitrogen application.
Source builtin.com
Sabanto
Illinois
Retrofit kits and software that make small farm tractors run autonomously.
Source builtinchicago.org
Salin 247
Ames, IA
Lightweight autonomous electric planters and sprayers that reduce soil compaction.
Source cals.iastate.edu
SkySpecs
Ann Arbor, MI
Autonomous drone inspection plus asset software for wind turbines.
Sources roboticsroundup.substack.com, purpose.jobs
Snowbotix
All-electric, all-terrain robot for snow and ice management (piloted at Grand Rapids airport).
Source purpose.jobs
Tapster Robotics
Oak Park, IL
Robots that physically tap and swipe phones and touchscreens for automated device testing.
Source startupintros.com
ThorDrive
Cincinnati, OH
Autonomous driving system for airport cargo and baggage tractors.
Source purpose.jobs
Unload
Eden Prairie, MN
Warehouse automation with horizontal-moving robots for dense storage and order fulfillment.
Source inven.ai
Virtual Incision
Lincoln, NE
MIRA miniaturized, single-incision robotic-assisted surgery platform.
Source biospace.com
Zenblen
Chicago, IL
Robotic smoothie bar that blends fresh smoothies automatically (mHUB member).
Source builtinchicago.org
Each company links the public page that names it. Where it is comes from its sources: a city, or only the state when that is all they say.